Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity

The constitutively active mutant of the Wiskott-Aldrich Syndrome protein (CA-WASp) is the cause of X-linked neutropenia and is linked with genomic instability and myelodysplasia. CA-WASp generates abnormally high levels of cytoplasmic F-actin through dysregulated activation of the Arp2/3 complex lea...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Moulding, D.A., Moeendarbary, E., Valon, L., Record, J., Charras, G.T., Thrasher, A.J.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338607/
https://ncbi.nlm.nih.gov/pubmed/22972986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-419663
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