Identification and Saturable Nature of Signaling Pathways Induced by Metreleptin in Humans: Comparative Evaluation of In Vivo, Ex Vivo, and In Vitro Administration

Signaling pathways activated by leptin in metabolically important organs have largely been studied only in animal and/or cell culture studies. In this study, we examined whether leptin has similar effects in human peripheral tissues in vivo, ex vivo, and in vitro and whether the response would be di...

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Bibliographic Details
Published in:Diabetes
Main Authors: Moon, Hyun-Seuk, Huh, Joo Young, Dincer, Fadime, Schneider, Benjamin E., Hasselgren, Per-Olof, Mantzoros, Christos S.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2015
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338590/
https://ncbi.nlm.nih.gov/pubmed/25249580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0625
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