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Near-infrared triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity in vivo

The gelatinase members of the MMP family have consistently been associated with tumor invasiveness, which make them an attractive target for molecular imaging. We report new activatable proteolytic optical imaging agents that consist of triple-helical peptide (THP) conjugates, with high specificity...

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Bibliografische gegevens
Gepubliceerd in:Bioorg Med Chem Lett
Hoofdauteurs: Zhang, Xuan, Bresee, Jamee, Fields, Gregg B., Edwards, W. Barry
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338581/
https://ncbi.nlm.nih.gov/pubmed/25047578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.06.072
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