Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease for which a greater understanding of early disease mechanisms is needed to reveal novel therapeutic targets. We report the use of human induced pluripotent stem cell (iPSC)-derived motoneurons (MNs) to study the pathophys...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Devlin, Anna-Claire, Burr, Karen, Borooah, Shyamanga, Foster, Joshua D., Cleary, Elaine M., Geti, Imbisaat, Vallier, Ludovic, Shaw, Christopher E., Chandran, Siddharthan, Miles, Gareth B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338554/
https://ncbi.nlm.nih.gov/pubmed/25580746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6999
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