MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1α and PPARγ

In hepatitis B virus (HBV)-replicating hepatocytes, miR-130a expression was significantly reduced. In a reciprocal manner, miR-130a reduced HBV replication by targeting at two major metabolic regulators PGC1α and PPARγ, both of which can potently stimulate HBV replication. We proposed a positive fee...

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Vydáno v:RNA
Hlavní autoři: Huang, Jyun-Yuan, Chou, Shu-Fan, Lee, Jun-Wei, Chen, Hung-Lin, Chen, Chun-Ming, Tao, Mi-Hua, Shih, Chiaho
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2015
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338335/
https://ncbi.nlm.nih.gov/pubmed/25595716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.048744.114
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