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Mathematical modeling of combinatorial regulation suggests that apparent positive regulation of targets by miRNA could be an artifact resulting from competition for mRNA

MicroRNAs bind to and regulate the abundance and activity of target messenger RNA through sequestration, enhanced degradation, and suppression of translation. Although miRNA have a predominantly negative effect on the target protein concentration, several reports have demonstrated a positive effect...

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Bibliografiske detaljer
Udgivet i:RNA
Main Authors: Nyayanit, Dimpal, Gadgil, Chetan J.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338329/
https://ncbi.nlm.nih.gov/pubmed/25576498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.046862.114
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