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Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes
OBJECTIVE: Dysregulated muscle metabolism is a cardinal feature of human insulin resistance (IR) and associated diseases, including type 2 diabetes (T2D). However, specific reactions contributing to abnormal energetics and metabolic inflexibility in IR are unknown. METHODS: We utilize flux balance c...
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| 發表在: | Mol Metab |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Elsevier
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4338313/ https://ncbi.nlm.nih.gov/pubmed/25737951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.12.012 |
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