High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene

OBJECTIVE: Association between prostate cancer and obesity remains controversial. Allelic deletions of PTEN, a tumor suppressor gene, are common in prostate cancer in men. Monoallelic Pten deletion in mice causes low prostatic intraepithelial neoplasia (mPIN). This study tested the effect of a hyper...

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Udgivet i:Mol Metab
Main Authors: Liu, Jehnan, Ramakrishnan, Sadeesh K., Khuder, Saja S., Kaw, Meenakshi K., Muturi, Harrison T., Lester, Sumona Ghosh, Lee, Sang Jun, Fedorova, Larisa V., Kim, Andrea J., Mohamed, Iman E., Gatto-Weis, Cara, Eisenmann, Kathryn M., Conran, Philip B., Najjar, Sonia M.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338312/
https://ncbi.nlm.nih.gov/pubmed/25737954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.12.011
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