The Fucosylation Inhibitor, 2-Fluorofucose, Inhibits Vaso-Occlusion, Leukocyte-Endothelium Interactions and NF-ĸB Activation in Transgenic Sickle Mice

2-Fluorofucose (2FF) blocks the fucosylation and the tethering of sialyl-Lewis(x) tetrasaccharide and structural variants on leukocytes and red blood cells to P- and E-selectins on activated endothelial cell surfaces. Because P- and E-selectin are required for vaso-occlusion in murine sickle cell di...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Belcher, John D., Chen, Chunsheng, Nguyen, Julia, Abdulla, Fuad, Nguyen, Phong, Nguyen, Minh, Okeley, Nicole M., Benjamin, Dennis R., Senter, Peter D., Vercellotti, Gregory M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338063/
https://ncbi.nlm.nih.gov/pubmed/25706118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117772
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados