Načítá se...

First-in-Human Dose Study of the Novel Transforming Growth Factor-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Patients with Advanced Cancer and Glioma

PURPOSE: TGFβ signaling plays a key role in tumor progression, including malignant glioma. Small-molecule inhibitors such as LY2157299 monohydrate (LY2157299) block TGFβ signaling and reduce tumor progression in preclinical models. To use LY2157299 in the treatment of malignancies, we investigated i...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Clin Cancer Res
Hlavní autoři: Rodon, Jordi, Carducci, Michael A., Sepulveda-Sánchez, Juan M, Azaro, Analia, Calvo, Emiliano, Seoane, Joan, Braña, Irene, Sicart, Elisabet, Gueorguieva, Ivelina, Cleverly, Ann L., Pillay, N. Sokalingum, Desaiah, Durisala, Estrem, Shawn T., Paz-Ares, Luis, Holdhoff, Matthias, Blakeley, Jaishri, Lahn, Michael M., Baselga, Jose
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337847/
https://ncbi.nlm.nih.gov/pubmed/25424852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1380
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!