Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer

Purpose Transforming growth factor-beta (TGF-β) signaling plays a key role in epithelial-mesenchymal transition (EMT) of tumors, including malignant glioma. Small molecule inhibitors (SMI) blocking TGF-β signaling reverse EMT and arrest tumor progression. Several SMIs were developed, but currently o...

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發表在:Invest New Drugs
Main Authors: Rodón, Jordi, Carducci, Michael, Sepulveda-Sánchez, Juan M., Azaro, Analía, Calvo, Emiliano, Seoane, Joan, Braña, Irene, Sicart, Elisabet, Gueorguieva, Ivelina, Cleverly, Ann, Pillay, N. Sokalingum, Desaiah, Durisala, Estrem, Shawn T., Paz-Ares, Luis, Holdhoff, Matthias, Blakeley, Jaishri, Lahn, Michael M., Baselga, Jose
格式: Artigo
語言:Inglês
出版: Springer US 2014
主題:
Phase I Studies
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387272/
https://ncbi.nlm.nih.gov/pubmed/25529192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-014-0192-4
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