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Permeability Transition Pore-dependent and PARP-mediated Depletion of Neuronal Pyridine Nucleotides During Anoxia and Glucose Deprivation

Exposure of rat cortical neurons to combined oxygen and glucose deprivation results in loss of NAD(P)H autofluorescence that is only partially reversible following restoration of oxygen and glucose, suggesting catabolism of pyridine nucleotides. This study tested the hypothesis that metabolic inhibi...

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Bibliografiske detaljer
Udgivet i:J Bioenerg Biomembr
Main Authors: Kahraman, Sibel, Siegel, Alex, Polster, Brian M., Fiskum, Gary
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337789/
https://ncbi.nlm.nih.gov/pubmed/25341378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10863-014-9588-2
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