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Permeability Transition Pore-dependent and PARP-mediated Depletion of Neuronal Pyridine Nucleotides During Anoxia and Glucose Deprivation

Exposure of rat cortical neurons to combined oxygen and glucose deprivation results in loss of NAD(P)H autofluorescence that is only partially reversible following restoration of oxygen and glucose, suggesting catabolism of pyridine nucleotides. This study tested the hypothesis that metabolic inhibi...

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Detalles Bibliográficos
Publicado en:J Bioenerg Biomembr
Main Authors: Kahraman, Sibel, Siegel, Alex, Polster, Brian M., Fiskum, Gary
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337789/
https://ncbi.nlm.nih.gov/pubmed/25341378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10863-014-9588-2
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