Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel

BACKGROUND AND PURPOSE: Memantine and ketamine are clinically used, open-channel blockers of NMDA receptors exhibiting remarkable pharmacodynamic similarities despite strikingly different clinical profiles. Although NMDA channel gating constitutes an important difference between memantine and ketami...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Emnett, Christine M, Eisenman, Lawrence N, Mohan, Jayaram, Taylor, Amanda A, Doherty, James J, Paul, Steven M, Zorumski, Charles F, Mennerick, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337705/
https://ncbi.nlm.nih.gov/pubmed/25377730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13007
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