Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction

BACKGROUND AND PURPOSE: The important pathological consequences of ischaemic heart disease arise from the detrimental effects of the accumulation of long-chain acylcarnitines in the case of acute ischaemia-reperfusion. The aim of this study is to test whether decreasing the L-carnitine content repre...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Liepinsh, E, Makrecka-Kuka, M, Kuka, J, Vilskersts, R, Makarova, E, Cirule, H, Loza, E, Lola, D, Grinberga, S, Pugovics, O, Kalvins, I, Dambrova, M
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337704/
https://ncbi.nlm.nih.gov/pubmed/25363063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13004
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