Distinct mechanisms regulating mechanical force-induced Ca(2+) signals at the plasma membrane and the ER in human MSCs

It is unclear that how subcellular organelles respond to external mechanical stimuli. Here, we investigated the molecular mechanisms by which mechanical force regulates Ca(2+) signaling at endoplasmic reticulum (ER) in human mesenchymal stem cells. Without extracellular Ca(2+), ER Ca(2+) release is...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kim, Tae-Jin, Joo, Chirlmin, Seong, Jihye, Vafabakhsh, Reza, Botvinick, Elliot L, Berns, Michael W, Palmer, Amy E, Wang, Ning, Ha, Taekjip, Jakobsson, Eric, Sun, Jie, Wang, Yingxiao
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337650/
https://ncbi.nlm.nih.gov/pubmed/25667984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04876
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