The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa

T follicular helper cells (Tfh) are crucial for the initiation and maintenance of germinal center (GC) reactions and high affinity, isotype-switched antibody responses. In this study, we demonstrate that direct TGF-β signaling to CD4 T cells is important for the formation of influenza-specific Tfh c...

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Veröffentlicht in:eLife
Hauptverfasser: Marshall, Heather D, Ray, John P, Laidlaw, Brian J, Zhang, Nianzhi, Gawande, Dipika, Staron, Matthew M, Craft, Joe, Kaech, Susan M
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2015
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337607/
https://ncbi.nlm.nih.gov/pubmed/25569154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04851
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