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On the Stability of Parainfluenza Virus 5 F Proteins

The crystal structure of the F protein (prefusion form) of the paramyxovirus parainfluenza virus 5 (PIV5) WR isolate was determined. We investigated the basis by which point mutations affect fusion in PIV5 isolates W3A and WR, which differ by two residues in the F ectodomain. The P22 stabilizing sit...

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Publicat a:J Virol
Autors principals: Poor, Taylor A., Song, Albert S., Welch, Brett D., Kors, Christopher A., Jardetzky, Theodore S., Lamb, Robert A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337539/
https://ncbi.nlm.nih.gov/pubmed/25589638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03221-14
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