Prevention of Glucocorticoid Induced-Apoptosis of Osteoblasts and Osteocytes by Protecting against Endoplasmic Reticulum (ER) Stress in vitro and in vivo in Female Mice

Endoplasmic reticulum (ER) stress is associated with increased reactive oxygen species (ROS), results from accumulation of misfolded/unfolded proteins, and can trigger apoptosis. ER stress is alleviated by phosphorylation of eukaryotic translation initiation factor 2α (eIF2α), which inhibits protein...

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Bibliographic Details
Published in:Bone
Main Authors: Sato, Amy Y., Tu, Xiaolin, McAndrews, Kevin A., Plotkin, Lilian I., Bellido, Teresita
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336847/
https://ncbi.nlm.nih.gov/pubmed/25532480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2014.12.012
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