A Versatile New Tool to Quantify Abasic Sites in DNA and Inhibit Base Excision Repair

A number of endogenous and exogenous agents, and cellular processes create abasic (AP) sites in DNA. If unrepaired, AP sites cause mutations, strand breaks and cell death. Aldehyde-reactive agent methoxyamine reacts with AP sites and blocks their repair. Another alkoxyamine, ARP, tags AP sites with...

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Bibliografiske detaljer
Udgivet i:DNA Repair (Amst)
Main Authors: Wei, Shanqiao, Shalhout, Sophia, Ahn, Young-Hoon, Bhagwat, Ashok S.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336807/
https://ncbi.nlm.nih.gov/pubmed/25616257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.12.006
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