Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche

BACKGROUND: Endothelial cells (ECs) are responsible for creating a tumor vascular niche as well as producing angiocrine factors. ECs demonstrate functional and phenotypic heterogeneity when located under different microenvironments. Here, we describe a tumor-stimulated mesenchymal phenotype in ECs a...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Ghiabi, Pegah, Jiang, Jie, Pasquier, Jennifer, Maleki, Mahtab, Abu-Kaoud, Nadine, Halabi, Najeeb, Guerrouahen, Bella S, Rafii, Shahin, Rafii, Arash
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336716/
https://ncbi.nlm.nih.gov/pubmed/25623554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0386-3
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