Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice.

MRL-lpr/lpr mice develop a generalized autoimmune disease which includes increased autoantibody production, glomerulonephritis, and development of lymphadenopathy. The lpr genetic defect has been identified as a mutation in the Fas apoptosis gene that results in low expression of Fas mRNA. To determ...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wu, J, Zhou, T, Zhang, J, He, J, Gause, W C, Mountz, J D
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1994
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC43367/
https://ncbi.nlm.nih.gov/pubmed/7510888
Etiketak: Etiketa erantsi
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