Action of Rifamycin Derivatives on RNA Polymerase of Human Leukemic Lymphocytes
The mechanism of inhibition of human RNA polymerase by four rifamycin derivatives was investigated. Derivative AF/013 (3-formyl rifamycin SV:O-n-octyloxime) with strong hydrophobic side chains prevents the polymerase from binding to DNA and also affects the size of RNA synthesized. Derivative PR/19...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1973
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433668/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4516206/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.7.2072 |
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