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Action of Rifamycin Derivatives on RNA Polymerase of Human Leukemic Lymphocytes

The mechanism of inhibition of human RNA polymerase by four rifamycin derivatives was investigated. Derivative AF/013 (3-formyl rifamycin SV:O-n-octyloxime) with strong hydrophobic side chains prevents the polymerase from binding to DNA and also affects the size of RNA synthesized. Derivative PR/19...

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Bibliografiske detaljer
Main Authors: Tsai, Ming-Jer, Saunders, Grady F.
Format: Artigo
Sprog:Inglês
Udgivet: 1973
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC433668/
https://ncbi.nlm.nih.gov/pubmed/4516206
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