Aldehyde Dehydrogenase-2 (ALDH2) Ameliorates Chronic Alcohol Ingestion-Induced Hepatic Steatosis and Inflammation: Role of Autophagy

BACKGROUND & AIMS: Mitochondrial aldehyde dehydrogenase (ALDH2) plays a critical role in the detoxification of the ethanol metabolite acetaldehyde. This study was designed to examine the impact of global ALDH2 overexpression on alcohol-induced hepatic steatosis. METHODS: Wild-type friendly virus...

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Bibliographic Details
Published in:J Hepatol
Main Authors: Guo, Rui, Xu, Xihui, Babcock, Sara A., Zhang, Yingmei, Ren, Jun
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336638/
https://ncbi.nlm.nih.gov/pubmed/25457208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2014.10.009
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