WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation

The TET2 DNA dioxygenase regulates cell identity and suppresses tumorigenesis by modulating DNA methylation and expression of a large number of genes. How TET2, like most other chromatin modifying enzymes, is recruited to specific genomic sites is unknown. Here we report that WT1, a sequence-specifi...

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Vydáno v:Mol Cell
Hlavní autoři: Wang, Yiping, Xiao, Mengtao, Chen, Xiufei, Chen, Leilei, Xu, Yanping, Lv, Lei, Wang, Pu, Yang, Hui, Ma, Shenghong, Lin, Huaipeng, Jiao, Bo, Ren, Ruibao, Ye, Dan, Guan, Kun-Liang, Xiong, Yue
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336627/
https://ncbi.nlm.nih.gov/pubmed/25601757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.12.023
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