Human Promoters Are Intrinsically Directional

Divergent transcription, in which reverse-oriented transcripts occur upstream of eukaryotic promoters in regions devoid of annotated genes, has been suggested to be a general property of active promoters. Here we show that the human basal RNA polymerase II transcriptional machinery and core promoter...

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Publicado en:Mol Cell
Autores principales: Duttke, Sascha H.C., Lacadie, Scott A., Ibrahim, Mahmoud M., Glass, Christopher K., Corcoran, David L., Benner, Christopher, Heinz, Sven, Kadonaga, James T., Ohler, Uwe
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336624/
https://ncbi.nlm.nih.gov/pubmed/25639469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.12.029
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