Functional cyclic AMP response element in the breast cancer resistance protein (BCRP/ABCG2) promoter modulates epidermal growth factor receptor pathway- or androgen withdrawal-mediated BCRP/ABCG2 transcription in human cancer cells

We report a novel cyclic-AMP (cAMP) response element (CRE) in the human BCRP promoter that is functional in human cancer cell lines of multiple lineages. 8Br-cAMP increased the activity of a BCRP promoter reporter construct and BCRP mRNA in human carcinoma cells. Activation of the epidermal growth f...

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Udgivet i:Biochim Biophys Acta
Main Authors: Xie, Yi, Nakanishi, Takeo, Natarajan, Karthika, Safren, Lowell, Hamburger, Anne W., Hussain, Arif, Ross, Douglas D.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336604/
https://ncbi.nlm.nih.gov/pubmed/25615818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2015.01.003
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