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The Extraordinary Catalytic Ability of Peroxiredoxins: a Combined Experimental and QM/MM Study on the Fast Thiol Oxidation Step

Peroxiredoxins (Prxs) catalyze the reduction of peroxides, a process of key relevance in a variety of cellular processes. The first step in the catalytic cycle of all Prxs is the oxidation of a cysteine residue to sulfenic acid, which occurs 10(3)-10(7) times faster than in free cysteine. We present...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Zeida, Ari, Reyes, Anibal M., Lebrero, Mariano C. G., Radi, Rafael, Trujillo, Madia, Estrina, Darío A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336542/
https://ncbi.nlm.nih.gov/pubmed/25045760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc02899f
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