Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice

INTRODUCTION: Lung-protective ventilation reduced acute respiratory distress syndrome (ARDS) mortality. To minimize ventilator-induced lung injury (VILI), tidal volume is limited, high plateau pressures are avoided, and positive end-expiratory pressure (PEEP) is applied. However, the impact of speci...

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Detalhes bibliográficos
Publicado no:Crit Care
Main Authors: Müller-Redetzky, Holger C, Felten, Matthias, Hellwig, Katharina, Wienhold, Sandra-Maria, Naujoks, Jan, Opitz, Bastian, Kershaw, Olivia, Gruber, Achim D, Suttorp, Norbert, Witzenrath, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336519/
https://ncbi.nlm.nih.gov/pubmed/25888164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-015-0759-2
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