4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity.

Deregulated signal transduction via the epidermal growth factor receptor (EGF-R) family of protein-tyrosine kinase growth factor receptors is associated with proliferative diseases. We describe a class of compounds (4,5-dianilinophthalimides) that inhibit the EGF-R protein-tyrosine kinase in vitro w...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Buchdunger, E, Trinks, U, Mett, H, Regenass, U, Müller, M, Meyer, T, McGlynn, E, Pinna, L A, Traxler, P, Lydon, N B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43365/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8134396/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.6.2334
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