4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity.

Deregulated signal transduction via the epidermal growth factor receptor (EGF-R) family of protein-tyrosine kinase growth factor receptors is associated with proliferative diseases. We describe a class of compounds (4,5-dianilinophthalimides) that inhibit the EGF-R protein-tyrosine kinase in vitro w...

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Hauptverfasser: Buchdunger, E, Trinks, U, Mett, H, Regenass, U, Müller, M, Meyer, T, McGlynn, E, Pinna, L A, Traxler, P, Lydon, N B
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC43365/
https://ncbi.nlm.nih.gov/pubmed/8134396
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