Activation of Toll-like receptor-2 by endogenous matrix metalloproteinase-2 modulates dendritic cell-mediated inflammatory responses

Matrix metalloproteinase-2 (MMP-2) is involved in several physiological mechanisms, including wound healing and tumor progression. We show that MMP-2 directly stimulates dendritic cells (DCs) to both up-regulate OX40L on the cell surface and secrete inflammatory cytokines. The mechanism underlying D...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Godefroy, Emmanuelle, Gallois, Anne, Idoyaga, Juliana, Merad, Miriam, Tung, Navpreet, Monu, Ngozi, Saenger, Yvonne, Fu, Yichun, Nair, Rajesh, Pulendran, Bali, Jotereau, Francine, Trombetta, Sergio, Bhardwaj, Nina
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336179/
https://ncbi.nlm.nih.gov/pubmed/25466255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.067
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