Matrix metalloproteinase-2 conditions human dendritic cells to prime inflammatory T(H)2 cells via an IL-12- and OX40L-dependent pathway

Matrix metalloproteinase-2 (MMP-2) is a proteolytic enzyme degrading the extracellular matrix and over-expressed by many tumors. Here, we documented the presence of MMP-2-specific CD4(+) T cells in tumor-infiltrating lymphocytes (TILs) from melanoma patients. Strikingly, MMP-2-specific CD4(+) T cell...

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Main Authors: Godefroy, Emmanuelle, Manches, Olivier, Dréno, Brigitte, Hochman, Tsivia, Rolnitzky, Linda, Labarrière, Nathalie, Guilloux, Yannick, Goldberg, Judith, Jotereau, Francine, Bhardwaj, Nina
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073826/
https://ncbi.nlm.nih.gov/pubmed/21397857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.01.037
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