Reorganization of corticostriatal circuits in healthy G2019S LRRK2 carriers

OBJECTIVE: We investigated system-level corticostriatal changes in a human model of premotor Parkinson disease (PD), i.e., healthy carriers of the G2019S LRRK2 mutation that is associated with a markedly increased, age-dependent risk of developing PD. METHODS: We compared 37 asymptomatic LRRK2 G2019...

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Vydáno v:Neurology
Hlavní autoři: Helmich, Rick C., Thaler, Avner, van Nuenen, Bart F.L., Gurevich, Tanya, Mirelman, Anat, Marder, Karen S., Bressman, Susan, Orr-Urtreger, Avi, Giladi, Nir, Bloem, Bastiaan R., Toni, Ivan
Médium: Artigo
Jazyk:Inglês
Vydáno: Lippincott Williams & Wilkins 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336002/
https://ncbi.nlm.nih.gov/pubmed/25540317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000001189
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