Hierarchical Data-Driven Analysis of Clinical Symptoms Among Patients With Parkinson's Disease

Mutations in the LRRK2 and GBA genes are the most common inherited causes of Parkinson's disease (PD). Studies exploring phenotypic differences based on genetic status used hypothesis-driven data-gathering and statistical-analyses focusing on specific symptoms, which may influence the validity...

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Главные авторы: Tal Kozlovski, Alexis Mitelpunkt, Avner Thaler, Tanya Gurevich, Avi Orr-Urtreger, Mali Gana-Weisz, Netta Shachar, Tal Galili, Mira Marcus-Kalish, Susan Bressman, Karen Marder, Nir Giladi, Yoav Benjamini, Anat Mirelman
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2019-05-01
Серии:Frontiers in Neurology
Предметы:
Parkinson's disease
G2019S-LRRK2
GBA
hierarchical testing
selective inference
Online-ссылка:https://www.frontiersin.org/article/10.3389/fneur.2019.00531/full
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