Evolution of Staphylococcus aureus under Vancomycin Selective Pressure: the Role of the Small-Colony Variant Phenotype

Staphylococcus aureus small-colony variants (SCVs) often persist despite antibiotic therapy. Against a 10(8)-CFU/ml methicillin-resistant S. aureus (MRSA) (strain COL) population of which 0%, 1%, 10%, 50%, or 100% was an isogenic hemB knockout (Ia48) subpopulation displaying the SCV phenotype, vanco...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Lenhard, Justin R., von Eiff, Christof, Hong, Irene S., Holden, Patricia N., Bear, Michael D., Suen, Amy, Bulman, Zackery P., Tsuji, Brian T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335873/
https://ncbi.nlm.nih.gov/pubmed/25451045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04508-14
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