Impact of Drug Resistance-Associated Amino Acid Changes in HIV-1 Subtype C on Susceptibility to Newer Nonnucleoside Reverse Transcriptase Inhibitors

The objective of this study was to assess the phenotypic susceptibility of HIV-1 subtype C isolates, with nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance-associated amino acid changes, to newer NNRTIs. A panel of 52 site-directed mutants and 38 clinically derived HIV-1 subtype C clo...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Basson, Adriaan E., Rhee, Soo-Yon, Parry, Chris M., El-Khatib, Ziad, Charalambous, Salome, De Oliveira, Tulio, Pillay, Deenan, Hoffmann, Christopher, Katzenstein, David, Shafer, Robert W., Morris, Lynn
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335849/
https://ncbi.nlm.nih.gov/pubmed/25421485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04215-14
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