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The energy blocker inside the power house: mitochondria targeted delivery of 3-bromopyruvate
A key hallmark of many aggressive cancers is accelerated glucose metabolism. The enzymes that catalyze the first step of glucose metabolism are hexokinases. Elevated levels of hexokinase 2 (HK2) are found in cancer cells, but only in a limited number of normal tissues. Metabolic reprogramming of can...
Enregistré dans:
| Publié dans: | Chem Sci |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Royal Society of Chemistry
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4335358/ https://ncbi.nlm.nih.gov/pubmed/25709804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc01963f |
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