Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer

PURPOSE: This study characterized the therapeutic efficacy of a systemically administered formulation of 3-bromopyruvate (3-BrPA), microencapsulated in a complex with β-cyclodextrin (β-CD), using an orthotopic xenograft mouse model of pancreatic ductal adenocarcinoma (PDAC). EXPERIMENTAL DESIGN: The...

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Publicado no:Clin Cancer Res
Main Authors: Chapiro, Julius, Sur, Surojit, Savic, Lynn Jeanette, Ganapathy-Kanniappan, Shanmugasundaram, Reyes, Juvenal, Duran, Rafael, Thiruganasambandam, Sivarajan Chettiar, Moats, Cassandra Rae, Lin, MingDe, Luo, Weibo, Tran, Phuoc T., Herman, Joseph M., Semenza, Gregg L., Ewald, Andrew J., Vogelstein, Bert, Geschwind, Jean-François
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300523/
https://ncbi.nlm.nih.gov/pubmed/25326230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1271
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