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N-Acetylglucosaminidases from CAZy Family GH3 Are Really Glycoside Phosphorylases, Thereby Explaining Their Use of Histidine as an Acid/Base Catalyst in Place of Glutamic Acid

CAZy glycoside hydrolase family GH3 consists primarily of stereochemistry-retaining β-glucosidases but also contains a subfamily of β-N-acetylglucosaminidases. Enzymes from this subfamily were recently shown to use a histidine residue within a His-Asp dyad contained in a signature sequence as their...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Macdonald, Spencer S., Blaukopf, Markus, Withers, Stephen G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335228/
https://ncbi.nlm.nih.gov/pubmed/25533455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.621110
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