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Chronic SSRI stimulation of astrocytic 5-HT(2B) receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift

It is firmly believed that the mechanism of action of SSRIs in major depression is to inhibit the serotonin transporter, SERT, and increase extracellular concentration of serotonin. However, this undisputed observation does not prove that SERT inhibition is the mechanism, let alone the only mechanis...

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Detalhes bibliográficos
Publicado no:Front Behav Neurosci
Main Authors: Hertz, Leif, Rothman, Douglas L., Li, Baoman, Peng, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335176/
https://ncbi.nlm.nih.gov/pubmed/25750618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2015.00025
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