Type II NKT-T(FH) cells against Gaucher lipids regulate B-cell immunity and inflammation

Chronic inflammation including B-cell activation is commonly observed in both inherited (Gaucher disease [GD]) and acquired disorders of lipid metabolism. However, the cellular mechanisms underlying B-cell activation in these settings remain to be elucidated. Here, we report that β-glucosylceramide...

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Pubblicato in:Blood
Autori principali: Nair, Shiny, Boddupalli, Chandra Sekhar, Verma, Rakesh, Liu, Jun, Yang, Ruhua, Pastores, Gregory M., Mistry, Pramod K., Dhodapkar, Madhav V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2015
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335081/
https://ncbi.nlm.nih.gov/pubmed/25499455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-09-600270
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