DNA-PK – a candidate driver of hepatocarcinogenesis and tissue biomarker that predicts response to treatment and survival

PURPOSE: Therapy resistance and associated liver disease make hepatocellular cancers (HCC) difficult to treat with traditional cytotoxic therapies, while newer targeted approaches offer only modest survival benefit. We focused on DNA-dependent protein kinase, DNA-PKcs, encoded by PRKDC and central t...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Cornell, Liam, Munck, Joanne, Alsinet, Clara, Villanueva, Augusto, Ogle, Laura, Willoughby, Catherine, Televantou, Despina, Thomas, Huw, Jackson, Jennifer, Burt, Alastair, Newell, David, Rose, John, Manas, Derek M, Shapiro, Geoffrey, Curtin, Nicola, Reeves, Helen L
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335075/
https://ncbi.nlm.nih.gov/pubmed/25480831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0842
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