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Novel Hg(2+)-Induced Nephropathy in Rats and Mice Lacking Mrp2: Evidence of Axial Heterogeneity in the Handling of Hg(2+) Along the Proximal Tubule
The role of the multi-resistance protein 2 (Mrp2) in the nephropathy induced by inorganic mercuric mercury (Hg(2+)) was studied in rats (TR(−)) and mice (Mrp2(−/−)), which lack functional Mrp2, and control animals. Animals were exposed to nephrotoxic doses of HgCl(2). Forty-eight or 24 hours after e...
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| Publicado no: | Toxicol Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4334813/ https://ncbi.nlm.nih.gov/pubmed/25145654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu171 |
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