Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

Background. The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13 (K13) have been associated with resistance in vitro and in field samples from Cambodia. Methods. P. fal...

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Udgivet i:J Infect Dis
Main Authors: Takala-Harrison, Shannon, Jacob, Christopher G., Arze, Cesar, Cummings, Michael P., Silva, Joana C., Dondorp, Arjen M., Fukuda, Mark M., Hien, Tran Tinh, Mayxay, Mayfong, Noedl, Harald, Nosten, Francois, Kyaw, Myat P., Nhien, Nguyen Thanh Thuy, Imwong, Mallika, Bethell, Delia, Se, Youry, Lon, Chanthap, Tyner, Stuart D., Saunders, David L., Ariey, Frederic, Mercereau-Puijalon, Odile, Menard, Didier, Newton, Paul N., Khanthavong, Maniphone, Hongvanthong, Bouasy, Starzengruber, Peter, Fuehrer, Hans-Peter, Swoboda, Paul, Khan, Wasif A., Phyo, Aung Pyae, Nyunt, Myaing M., Nyunt, Myat H., Brown, Tyler S., Adams, Matthew, Pepin, Christopher S., Bailey, Jason, Tan, John C., Ferdig, Michael T., Clark, Taane G., Miotto, Olivo, MacInnis, Bronwyn, Kwiatkowski, Dominic P., White, Nicholas J., Ringwald, Pascal, Plowe, Christopher V.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Major Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334802/
https://ncbi.nlm.nih.gov/pubmed/25180241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu491
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