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A Temperature-Sensitive Mutation Affecting 28S Ribosomal RNA Production in Mammalian Cells

We have characterized a temperature-sensitive (ts) mutant of the hamster cell line BHK 21 that appears to have a defect in the processing of ribosomal RNA precursors at 39°. Mutant ts 422E grows at a normal rate at 33°, but upon shift to 39° growth stops after about one cell doubling. The appearance...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Toniolo, Daniela, Meiss, Harriet K., Basilico, Claudio
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1973
Témata:
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433474/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4515626/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.4.1273
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