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A Temperature-Sensitive Mutation Affecting 28S Ribosomal RNA Production in Mammalian Cells

We have characterized a temperature-sensitive (ts) mutant of the hamster cell line BHK 21 that appears to have a defect in the processing of ribosomal RNA precursors at 39°. Mutant ts 422E grows at a normal rate at 33°, but upon shift to 39° growth stops after about one cell doubling. The appearance...

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Detalhes bibliográficos
Main Authors: Toniolo, Daniela, Meiss, Harriet K., Basilico, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: 1973
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC433474/
https://ncbi.nlm.nih.gov/pubmed/4515626
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