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An Adaptive, Phase II, Dose-Finding Clinical Trial Design to Evaluate l-Carnitine in the Treatment of Septic Shock Based on Efficacy and Predictive Probability of Subsequent Phase III Success

OBJECTIVES: Sepsis is the tenth leading cause of death in the United States. Despite extensive research, mortality rates for sepsis have not substantially improved in the last several decades. We describe an innovative phase II clinical trial design for evaluating the addition of l-carnitine to the...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Crit Care Med
Main Authors: Lewis, Roger J., Viele, Kert, Broglio, Kristine, Berry, Scott M., Jones, Alan E.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334380/
https://ncbi.nlm.nih.gov/pubmed/23514753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0b013e318287f850
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