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A Mutated Anti-CA19-9 scFv-Fc for Positron Emission Tomography of Human Pancreatic Cancer Xenografts
PURPOSE: Intact antibodies have a long serum persistence resulting in high background signal that inhibits their direct translation as imaging agents. Engineering of antibody fragments through the introduction of mutations in the fragment crystallizable (Fc) region can dramatically reduce serum pers...
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| Publicat a: | Mol Imaging Biol |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4334371/ https://ncbi.nlm.nih.gov/pubmed/24691872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-014-0733-4 |
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